https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Optimization of microwave-assisted extraction of polyphenols from lemon myrtle: Comparison of modern and conventional extraction techniques based on bioactivity and total polyphenols in dry extracts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48605 Wed 22 Mar 2023 09:01:15 AEDT ]]> In vitro antibacterial and anticancer properties of Helicteres hirsuta Lour. leaf and stem extracts and their fractions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37074 Helicteres hirsuta Lour. (H. hirsuta) has been considered as a herbal medicine for the treatment of malaria and diabetes but limited studies have been conducted on its anticancer and antibacterial properties. In this study, the in vitro antibacterial and anticancer properties of the leaf and stem extracts and their two sub-fractions (aqueous and saponin-enriched butanol fractions) prepared from H. hirsuta were elucidated. MTT and CCK-8 assays were employed to assess their in vitro anticancer properties against various cancer cell lines. The antibacterial activity was assessed using the disc diffusion method and minimum inhibitory concentration (MIC) values were determined. The results revealed that the saponin-enriched fractions from H. hirsuta leaves and stems showed the highest antibacterial activity against E. coli (MIC values of 2.50 and 5.00 mg/mL, respectively) and S. lugdunensis (MIC values of 0.35 and 0.50 mg/mL, respectively). Importantly, these saponin-enriched fractions possessed strong anticancer activity in vitro towards a range of cancer cell lines including MIA PaCa-2 (pancreas); A2780 (ovarian); H460 (lung); A431 (skin); Du145 (prostate); HT29 (colon); MCF-7 (breast); SJ-G2, U87, SMA (glioblastoma) and BE2-C (neuroblastoma) at low doses (GI₅₀ values of 0.36–11.17 µg/mL). They especially revealed potent anti-pancreatic cancer activity in vitro against MIA PaCa-2, BxPC-3 and CFPAC-1 cells with IC50 values of 1.80–6.43 µg/mL. This finding provides scientific evidence of the cytotoxic activity of the extracts prepared from H. hirsuta leaves and stems, and suggests further studies to isolate active compounds for development of new anticancer agents from these plant extracts.]]> Wed 19 Jan 2022 15:15:13 AEDT ]]> Inhibitors of bacterial RNA polymerase transcription complex https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47118 Wed 14 Dec 2022 12:25:36 AEDT ]]> Borophene Embedded Cellulose Paper for Enhanced Photothermal Water Evaporation and Prompt Bacterial Killing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50279 Wed 12 Jul 2023 16:38:07 AEST ]]> Green synthesis and antibacterial potential of artemisia vulgaris extract in silver nanoparticles against wound bacteria https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49923 Thu 15 Jun 2023 11:20:40 AEST ]]> Bacterial transcription as a target for antibacterial drug development https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29829 Sat 24 Mar 2018 07:40:53 AEDT ]]> Protein-protein interactions as antibiotic targets: a medicinal chemistry perspective https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46213 Mon 14 Nov 2022 11:58:08 AEDT ]]> Zn-Loaded SBA-1 and SBA-15 Molecular Sieves for Combined Antimicrobial and Osteogenic Activity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50510 Mon 07 Aug 2023 13:39:52 AEST ]]> Phytochemicals derived from Australian eucalypts as anticancer agents for pancreatic malignancies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32711 Fri 20 Sep 2019 02:27:30 AEST ]]>